The risk of reproductive cancers (ovarian, uterine, mammarian) for an unspayed female rabbit stands at is virtually eliminated by spaying your female rabbit. Your neutered male rabbit will live longer as well, given that he won't be tempted to fight with other animals (rabbits, cats, etc.) due to his sexual aggression.
Surgery can be as safe on rabbits as on any animal. Unfortunately, the vast majority of veterinarians aren't experienced with safe rabbit surgery techniques. Don't allow a veterinarian with little or no experience with rabbits spay or neuter your rabbit. Using isofluorene as the anesthetic and appropriate surgical and after-surgery techniques, spaying and neutering of rabbits is as safe as for any other animal.
Females can be spayed as soon as they sexually mature, usually around 4 months of age, but many veterinarians prefer to wait until they are 6 months old, as surgery is riskier on a younger rabbit.Males can be neutered as soon as the testicles descend, usually around 3-1/2 months of age.
When is a rabbit too old to be spayed or neutered? veterinarians will have their own opinions on this, but in general, after a rabbit is 6 years old, anesthetics and surgery become more risky.It is always a good idea, in a rabbit over 2 years of age, to have a very thorough health check done, including full blood work. This may be more expensive than the surgery, but it will help detect any condition that could make the surgery more risky. This is especially important if anesthetics other than isofluorene are used.